• MAXILLOFACIAL SURGERY

Effect of platelet-rich plasma on chronic odontogenic maxillary sinusitis: a pilot study

DOI: https://doi.org/10.25241/stomaeduj.2019.6(2).art.4

Abstract

Introduction Chronic odontogenic maxillary sinusitis (CMOS) is a frequent inflammatory process, in the oro-maxilo-facial pathology. Platelet-rich plasma (PRP) is a natural source of growth factors, which have the potential to stimulate and accelerate the wound healing process. The aim of this study is to observe the effects of the PRP growth factors in patients with CMOS.
Methodology From five patients diagnosed with CMOS, we collected inflammatory oral mucosa and incubated with 2mL PRP for 7 days. PRP was obtained from venous blood collection from each patient. The control samples were represented by inflammatory sinus mucosa without the added of PRP. Using cell lysate we measured the following biomarkers: insulin receptor (IR) and insulin-like growth factor 1 receptor (IGF-1R), glycogen synthase kinase 3 beta (GSK3β), glycogen synthase kinase 3 alfa (GSK3α) performed by Multiplex technology.
Results The growth factors released from platelets should be regarded as a positive effect source in the case of patients diagnosed with CMOS. These growth factors should activate the oligopotente stem cells which will finally lead to sinus mucosa regeneration. Future studies are needed to understand the molecular mechanisms that occur at the sinus level.
Keywords Inflammation; Platelet-rich plasma (PRP); Sinusitis; Chronic odontogenic maxillary sinusitis (CMOS).

 

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