art-6-1-21

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                    OCCLUSION AND TMJ
                    CONDYLOGRAPHIC RECORDING OF MASTICATORY
Original Articles
                    FUNCTION: EXPLORATIVE STUDY ON OCCLUSAL
                    PARAMETERS AND CHEWING PERFORMANCE WITH
                    NATURAL FOOD AND A STANDARD FOOD MODEL
                    Giulia Tanteri1a , Carlotta Tanteri1b , Gregor Slavicek2,3c*

                    1Private Practice - Studio Tanteri, Turin, Italy;
                    2Steinbeis Transfer Institute Biomedical Interdisciplinary Dentistry, Steinbeis University Berlin, DE-12489 Berlin, Germany;
                    3OREHAB-Minds GmbH, DE-70567 Stuttgart, Germany

                    a
                      MD, MSc, Specialist in Maxillofacial Surgery; e-mail: tanteri@tanteri.it; ORCIDiD: https://orcid.org/0000-0002-3765-7722
                    b
                      DDS, MSc; e-mail: carlotta.tanteri@gmail.com; ORCIDiD: https://orcid.org/0000-0001-5560-5574
                    c
                     MD, DDS, MSc, Director and Head, CEO and Head; e-mail: gregor.slavicek@stw.de; ORCIDiD: https://orcid.org/0000-0003-2454-4048


                    ABSTRACT                                                                               https://doi.org/10.25241/stomaeduj.2021.8(1).art. 6

                    Introduction Loss of teeth defines oral health status and chewing abilities. Caries and periodontal disease
                    have been associated with systemic diseases, however they may contribute to cognitive impairment
                    too. Mastication assessment appears to possess broad significance, and is needed to create background
                    knowledge for chewing harmony. The aim of this study was to evaluate chewing performance and the
                    characteristics of condylographic recordings, during mastication of Natural Food (NF) and a Standard Food
                    Model (SFM), in subjects with different occlusal parameters.
                    Methodology Twenty-three adult subjects’ mastication was assessed with a standardized recording protocol,
                    when chewing onto SFM and NF in three different textures. Detailed occlusal characteristics, condylographic
                    recording data and condylographic patterns during mastication were all analyzed and compared.
                    Results Bilateral Crossbites, Missing Molars and Asymmetric Molar Class were related to higher disharmony
                    and transversal displacement during chewing. Missing and unreplaced molars showed dysfunctional
                    patterns and so did worn out occlusal surfaces. Molar Class alone did not prove to be a useful predictor in
                    chewing test results.
                    Conclusion Increasing evidence indicates that oral health has an impact on Individual and Public Health.
                    It is important to understand that oral health and its functional status are to be maintained during one’s
                    lifetime, and that preventive, therapeutic measures at all ages should have a common functional target to
                    grant neurobiological health as well as nutritional goals of Mastication. Further studies are needed to better
                    understand the relevance of additional parameters such as Occlusal Plane Inclination, Curve of Spee, and
                    three-dimensional asymmetries.

                    KEYWORDS
                    Mastication; Condylography; Axiography; Chewing Test; Occlusion.

                    1. INTRODUCTION                                                                  quality of mastication and its efficiency are crucial
                                                                                                     even beyond the individual ability to perform chew-
                    Throughout the history of medicine Mastication                                   ing strokes and to swallow. Oral health has been
                    has triggered the interest of researchers due to its                             held responsible for, or related to, a number of
                    complexity, its functions and behavioral significance.                           systemic conditions. For instance, poor oral health
                    Mastication is the process by which food is broken                               has been investigated in the past as an independent
                    down by teeth into smaller pieces, mixed with saliva                             risk factor and association for systemic diseases
                    into a bolus and made suitable for swallowing. The                               such as myocardial infarction, coronary disease and


                                   OPEN ACCESS This is an Open Access article under the CC BY-NC 4.0 license.
                                   Peer-Reviewed Article
                        Citation: Tanteri G, Tanteri C, Slavicek G. Condylographic recording of masticatory function: explorative study on occlusal parameters and chewing
                        performance with natural food and a standard food model. Stoma Edu J. 2021;8(1):52-64
                        Received: February 21, 2021; Revised: February 27, 2021; Accepted: March 02, 2021; Published: March 04, 2021
                        *Corresponding author: Dr. Gregor Slavicek, MD, DDS, MSc, Director and Head, CEO and Head OREHAB-Minds GmbH, Zettachring 2, DE-70567
                        Stuttgart, Germany
                        Tel./Fax: +49-7307-24922-11; e-mail: g.slavicek@orehab-minds.com
                        Copyright: © 2021 the Editorial Council for the Stomatology Edu Journal.




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Condylographic recording of chewing function
                                                                                                                                                         www.stomaeduj.com




                                                                                                                                                       Original Articles
                                                                          Figure 2. Quality of occlusal surfaces, from left to right: poor, average,
                                                                         good.

 Figure 1. Expected chewing pattern - example of right side chewing of
NF Carrot: ws displays shorter and steeper tracings as opposed to nws.
Movement is harmonic and superimposable, transversal aspects of
movement are contained.

 Table 1. Inclusion criteria.                                            hard and demanding quest which proceeded along
                                                                         with the development of ad hoc apparatuses and
 Inclusion criteria
                                                                         recording devices. Studies by Lundeen and Gibbs
 Subjects were considered for the study if the following                 from the 1980s showed that there are differences
 conditions were met:
                                                                         in chewing in relation to growth, and that they are
 - any Gender                                                            related to changes in form and function which take
 - good overall health status (no prescription drugs taken               place during transition from infancy to adulthood
 routinely, asymptomatic)                                                (increase in the steepness of the articular eminence,
 - no previous diagnosis of Temporomandibular Disorder                   development of the anterior tooth guidance, and
                                                                         change from deciduous to permanent teeth). Adults’
 - willingness to understand the procedure and give informed
                                                                         chewing pattern has a midsagittal opening and
 consent
                                                                         wide lateral closing movements when observed
diabetes [1-3]. This whole issue has reached a higher                    from a dental perspective [9,10]. The quality of the
and wider awareness only in recent times, although                       occlusion, conditions such as Temporomandibular
earlier studies concerning these associations had                        Disorders (TMJ) and interferences in occlusion all
already highlighted the importance of maintaining                        affect mastication: the more the interferences the
a satisfactory oral and dental status for the good of                    longer the chewing time and the more atypical the
systemic health and for the consequences on Public                       pattern looks [11]. Regarding patterns, Lundeen and
Health [4]. Among the above-mentioned conditions,                        Gibbs studied mastication with the Replicator System
Dementia has more recently been related to oral                          [9,10]. The Replicator System was an electronic jaw-
health and chewing impairment. Because of its                            movement recorder that allowed to replicate all
vigorous onset in the elderly populations, and                           border and chewing movements while also being
because the world population is more and more                            able to examine ‘chewing casts’ from all views. The
represented by the elder age group, Dementia                             authors’ evaluations of the chewing patterns were
has become an increasingly important health and                          made on occlusal points (first molars and interincisal),
socioeconomic issue [5].                                                 on both sides, as well as by tracking the joints.
It is fair to understand that, among other factors, the                  Studies concerning the masticatory patterns have
mere number of lost teeth defines not only one’s oral                    been described in previous works, the most notable
health status, but also his/her chewing abilities, with                  being the ones with the Sirognathograph first, and
subsequent forceful changes in diet, malnutrition,                       the Kinesiograph later on. This latter method can
and an inflammatory response which have all                              only identify movement of a single anterior point
been related to an increased risk of Dementia and                        with a magnet positioned on the lower arch, but it
Alzheimer’s Disease (AD). These emerging findings,                       has the possibility to study muscular activity through
besides harmony and good functioning of the                              Electromyography at the same time [12,13].
stomatognathic system, call for further studies on                       Researchers have also recognized a repetition and
mastication and on the significance of lost teeth,                       reproducibility of chewing patterns, with harmony
both for what concerns the number of missing                             also being a characteristic of a healthy chewing
teeth and what dental element in particular [6].                         function and, if harmony is missing, along with
Teeth possess discrimination for direction of                            repetition and a scheme, then a dysfunctional masti-
forces, texture and hardness of foods, thanks to the                     cation is observed. Malocclusions such as unilateral
interaction between pulp-dentine-enamel units and                        crossbite have shown a peculiar subversion of
periodontal ligaments [7,8]. Studying mastication                        opening and closing direction which are substantially
and the stomatognathic system has shown to be a                          different to the expected chewing pattern: in these



Stoma Edu J. 2021;8(1): 52-64                                                                pISSN 2360-2406; eISSN 2502-0285                             53
                     Tanteri G, et al.
www.stomaeduj.com


 Original Articles    Table 2. Exclusion criteria.

                      Exclusion criteria
                      Subjects were excluded if the following conditions were met:
                      - age below 18
                      - age above 70
                      - food allergy (nuts)
                      - vegetarian/vegan subjects
                      - hyperglycemia/diabetes
                      - permanence of deciduous teeth
                      - removable total/partial prostheses
                      - ongoing orthodontic treatment
                      - any dental extraction/dental surgery in the previous 6 months
                      - composite/filling on occlusal surfaces in the previous 6 months
                      - acute oral health issue (caries, odontogenic abscess, odontogenic phlegmon)
                      - acute craniofacial issue (trauma with/without fractures)
                      - acute/chronic pain of masticatory and facial muscles
                      - primary headaches
                      - chronic neck, shoulders or back pain (pain >3 months)
                      - previous brain injuries
                      - cleft palate/lips
                      - facial clefts
                      - impaired saliva production due to drugs or systemic disease
                      - mental illness
                      - visual impairments (sightless subjects)
                      - neurological disorder with impaired motor capabilities with/without medication
                      - neurological conditions affecting cranial nerves
                      - any condition influencing proper informed consent to participation in the study
                      - any conditioning affecting the sitting position in a dental chair




                      Figure 3. Standard Food Model jellies, from left to right: soft, medium and
                     hard texture.


                     cases, the mandible will first move medially during
                     opening and then laterally, so as to confront with
                     the ‘crossed’ surfaces of antagonist teeth. Moreover,                            Figure 4. Tool for calculating areas of condylographic tracings in sagittal,
                     this altered pattern has a narrower width and a                                cranial and frontal view. In this figure, the sagittal tracing was digitally out-
                                                                                                    lined and in the bottom right-hand corner are the perimeter and the area
                     more vertical closing angle. If the ‘Functional Matrix’                        of the right sagittal condylographic tracing. The same procedure was carried
                     of Moss is not to be forgotten, this supposedly has                            out for all planes (sagittal, cranial and frontal) on both sides for all chewing.
                     some effect on growing children, both structurally
                     and with respect to motor control, and it is the                               thus making the standardization for the masticatory
                     reason why unilateral crossbite can be looked at as a                          tests difficult. Natural foods that are mostly described
                     ‘neuromuscular syndrome’ [12,14].                                              by authors are: peanuts, almonds, cocoa, carrots,
                     Some studies have explored human mastication                                   hazelnuts, decaffeinated coffee beans and nuts
                     through chewing tests and their outcome. Kikui                                 [16-21]. Previous experience with the limitations of
                     and colleagues for instance assessed comminution                               natural foods chewing tests brought about the need
                     of a jelly, claiming that it was a valid method for                            for an ideal food model for experimental, research
                     gathering relevant information from the number of                              and clinical testing. With this respect a Standard
                     pieces and their surface area.                                                 Food Model (SFM) was first developed, described
                     This better replicates in their opinion what actually                          and proposed by Slavicek in 2009 [22-26]. Such
                     occurs during effective chewing: crushing and an                               food model has been produced in a short cylindrical
                     increase in the surface area of food, so as to facilitate                      shape and three different hardnesses (A. Egger' Sohn,
                     reaction with digestive enzymes, decomposition,                                Süsswaren und Naturmittel GmbH., Mellergasse 4,
                     and the absorption of nutrients [15]. Some other                               A-1230 Vienna, Austria).
                     tests use natural foods as a material test, however                            Condylography as a method for evaluating mandi-
                     physical properties of natural foods vary and are                              bular movements has its predecessors dating as back
                     difficult to standardize. There are natural variations                         as the last decades of the 1800s. The first recordings
                     in size and texture which produce differences in the                           were reported by Ulrich and Walker, and invaluable
                     final outcomes. Besides, hardness is not constant,                             contributions to the study of hinge axis, Bennett
                     due to the various degrees of water incorporation                              movement, jaw tracking, articulator programming



    54               Stoma Edu J. 2021;8(1): 52-64                                                                        pISSN 2360-2406; eISSN 2502-0285
Condylographic recording of chewing function
                                                                                                                                         www.stomaeduj.com




                                                                                                                                       Original Articles
Table 3. Condylographic data collected directly from the recording software.
 Software-retrieved data for analysis of Mastication
 Maximum displacement (s) of the hinge axis (mm) for both the working side and the non-working side (ws and nws) assessed on
 the sagittal plane
 Sagittal Condylar Inclination SCI° (inclination of the hinge axis excursion) for both the working side and the non-working side (ws
 and nws)

Table 4. Condylographic data calculated from tracings with the use of an additional tool.

 Calculations for analysis of Mastication
 Sagittal area for both working side and non-working side (mm2)
 Transversal cranial area for both working side and non-working side (mm2)
 Transversal frontal area for both working side and non-working side (mm2)
 Ratio sagittal: cranial for both working side and non-working side
 Ratio sagittal: frontal for both working side and non-working side




Figure 5. Molar Class Right and Left – Distribution Females.

and for diagnostic purposes have been made by                            correlation had been hypothesized even earlier,
Bennett, Eltner, Gysi, McCollum, Posselt, Messerman,                     when basic findings were retrieved highlighting
Bewersdorff, Jankelson, Lundeen, Alsawaf, Missert                        the fact that Dementia patients were more likely to
and Slavicek [27].                                                       have a greater tooth loss [35,36]. However different
Caries, periodontal disease and systemic conditions                      studies and authors have aspired to study this
that can affect the periodontium, can all potentially                    relationship as a predisposing condition, similarly to
lead to tooth loss. Tooth loss can somewhat be                           what has been done with the correlation between
prevented and has therefore been the target for                          cardiovascular disease and periodontitis. A 5-year
Public Health measures, but nevertheless it is still                     prospective cohort study investigated the effect
common, especially within the ageing population                          of tooth loss on the development of Mild Memory
and in the lower socio-economic groups [28,29].                          Impairment (MMI) among the elderly [31]. A study
What is mostly unforeseen or prevented, but is just                      on identical twins revealed that major tooth loss
as common, is Dementia, the most frequent being                          before the age of 35 was a significant risk factor for
Alzheimer’s Disease (AD).                                                AD [32]. A study on a population of nuns, found that
A World Health Organization report from 2013 stated                      9 or fewer remaining teeth were associated with an
that the total number of people with Dementia                            increased risk of Dementia [33].
worldwide in 2010 was estimated at 35.6 million                          Type 2 Diabetes patients were the target of a
and is deemed to almost double every 20 years, to                        prospective cohort study that showed that Demen-
65.7 million in 2030 and 115.4 million in 2050 [30].                     tia and cognitive decline are associated with having
AD occurs because of environmental, genetic and                          no teeth [37]. Conversely, the presence of teeth,
vascular risk factors, yet nearly half of ADs do not                     or better, the preservation of natural teeth and
have a clear mutation or cause [6]. A relationship                       cognitive functioning have shown a significant posi-
between AD and tooth loss has been sought for at                         tive relationship [38]. Worse episodic memory has
least twenty years now, with publications focusing                       been assessed in other studies and it has been
on the transition from memory impairment to AD,                          correlated with tooth number, too [39]. Okamoto
on oral health in nursing homes, cohort studies                          and colleagues also reported about a survey study
and community homes for the elderly [31-34]. This                        that claimed that patients with MMI will more



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                     Tanteri G, et al.
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 Original Articles



                     Figure 6. Molar Class Right and Left – Distribution Males.

                     likely progress into AD as opposed to other types            and memory [8,42-46]. A pilot study by Elsig allowed
                     of dementia, thus making MMI (examined through               to point out a difference between the number of
                     the Mini-Mental State Examination - MMSE) a good             remaining teeth and chewing efficacy in Dementia
                     time-frame for evaluations of this kind [40]. In the         patients, thus further encouraging the performance
                     Fujiwara-kyo study a population of 3696 healthy              of routine chewing tests besides tooth count in
                     residents over the age of 65, was observed from              geriatric evaluations [47]. Mastication and its study
                     2007 to 2012. Among these, 2486 underwent follow-            appear to possess significance both individually,
                     up examination and 2335 were included in the final           in terms of prediction of disease or its risk, for its
                     analysis (only cognitively intact or MMI subjects).          educational value, and in order to create a wider
                     This very powerful and well-designed study showed            database for chewing patterns and unfavorable occ-
                     that tooth loss and worse cognitive performance              lusal features, which will enable to fulfill the afore-
                     are indeed correlated, and that absence of tooth             mentioned purposes.
                     loss and preservation of the patients’ baseline status       The aim of this study was to assess the characteristics
                     meant no increase in risk of MMI [31].                       of condylographic tracings, during mastication of
                     Possible reasons for the association between memory          natural food (NF) and a standard food model (SFM),
                     disorder and tooth loss have been highlighted not            in subjects with different occlusal parameters.
                     only in the Fujiwara-kyo paper: the existence of an          Based on the existing literature, the purpose was
                     inflammatory status related to periodontal disease           to evaluate whether condylography was suitable
                     which caused tooth loss; genetic factors related to          for tracking mastication at the temporomandibular
                     both MMI and periodontal disease; and a decrease             joint (TMJ), to evaluate whether condylography
                     in sensory receptors function. An observational              could reliably provide a clear tracing aspect working
                     study published in 2015 aimed at drawing some                (ws) versus non-working side (nws) with the ws
                     associations between tooth loss and Dementia from            being steeper, straighter and shorter as opposed to
                     the late 1960s onwards [41].                                 the nws (see Fig. 1), if disharmony or subversion of
                     The hypothesis behind this retrospective analysis            the abovementioned aspect of ws and nws for some
                     of a cohort of women was that tooth loss was an              occlusal features (flat occlusal surfaces, missing
                     expression of some proinflammatory activity and              teeth,...) and food properties.
                     that there was a correlation between the number
                     of teeth and Dementia. Mastication influences the            2. MATERIALS AND METHODS
                     activity in the cerebral cortex, stimulating cognitive
                     function and preventing brain degradation.                   Twenty-three adult subjects’ mastication was asse-
                     Rhythmic movements, and this may be one reason               ssed by means of condylography with a standar-
                     why sports have a similar beneficial effect, increase        dized recording protocol, when chewing onto SFM
                     blood flow especially in the prefrontal cortex and           and NF in three different textures (for SFM: hard,
                     the hippocampus, where learning and memory                   medium, soft; for NF: salad leaf, carrot slice, nut). The
                     performance reside [31,38].                                  study protocol followed the ethical guidelines of the
                     Thorough dissertation on the role of chewing,                Declaration of Helsinki, and informed consent prior
                     hippocampal, reticular formation and somatosensory           to recording was acquired from all subjects (see Tabs.
                     associations is not the scope of this paper, however         1 and 2). Sagittal first molar relationship (Class 1, 2 and
                     impoverishment of chewing abilities and function             3) was recorded for each subject and each side (right
                     through alteration in number or quality of occlusal          and left). Asymmetric molar classes were included in
                     determinants (extraction or milling of molars) and           the data collection. The presence of a Clear Buccal
                     a long-term soft-diet feeding, can inhibit learning          Intercuspation was checked according to the clinical



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Condylographic recording of chewing function
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                                                                                                                                                                Original Articles
  Figure 7. Mann-Whitney U Test results for differences in sagittal (xz plane     Figure 8. Mann-Whitney U Test results for differences in sagittal (xz plane
of condylography) to transversal (yz and xy planes) ratios of chewing           of condylography) to transversal (yz and xy planes) ratios of chewing
tracings for SFM and NF in Asymmetric Molar Class (Y/N).                        tracings for SFM and NF in Asymmetric Molar Class (Y/N).


assessment of a distinct 1:2 vestibular relationship                            underwent a condylographic recording session
between upper and lower arches. Other sagittal and                              during which a standard recording and a chewing
transversal intermaxillary dental relationships were                            recording were performed. The condylography was
recorded as well: open bite (when overbite<0 mm),                               carried out by using an electronic recording system
deep bite (when overbite>4 mm), bilateral crossbite,                            for jaw movements (Cadiax Diagnostic GAMMA
monolateral crossbite, scissor bite. The presence                               Dental, ®GAMMA med. wiss. Fortbildungs GmbH,
and location of missing teeth and prosthodontic/                                Josef Brennerstr. 10, A-3400 Klosterneuburg, Austria).
conservative restorations were recorded too.                                    One trained investigator performed all recordings. A
Occlusal surface characteristics were evaluated as                              paraocclusal clutch was applied, the hinge axis was
Good, Average or Poor based on the investigators’                               localized and classic condylographic recording of
assessment on overall tooth wear (Fig. 2). All subjects                         movements would take place before the chewing



Stoma Edu J. 2021;8(1): 52-64                                                                        pISSN 2360-2406; eISSN 2502-0285                              57
                     Tanteri G, et al.
www.stomaeduj.com


 Original Articles    Table 5. Quality of occlusal surfaces (right side).       Table 6. Quality of occlusal surfaces (left side).

                                                             # of subjects                                             # of subjects
                      Poor                                         9             Poor                                         8
                      Average                                      6             Average                                      8
                      Good                                         8             Good                                         7


                     recording session. A previously developed and              was detected in 5 subjects (21.7%). See Gender
                     described Standard Food was used in three different        distribution in Figs. 5 and 6. The Open Bite was
                     textures (soft, medium and hard) (A. Egger´ Sohn,          present in 3 subjects overall (13%), whereas Deep
                     Süsswaren und Naturmittel GmbH, Mellergasse 4,            Bite was found in 30.4% of subjects (7 probands).
                     A-1230 Vienna, Austria). The shape of these jellies        The Open bite was present in 2 cases of Class 1
                     was cylindrical and the size was 10x20 mm (Fig. 3).        molar relationships (16.67% of all class 1) and in 1
                     The recordings were strictly performed for 18 seconds,     case (11.11%) with molar class 2, both for the right
                     on each side (right, left and bilateral chewing),          side. For the left side, the open bite was present in 2
                     for each texture of jellies and for each type of natural   cases (18.2%) in Molar Class 1 and in 1 case (16.7%)
                     food. Eighteen seconds were mandatory because              for class 2. No open bite was related to Molar Class
                     of the maximum recording time the software could           3 on either side. The Deep Bite was mostly present
                     host.                                                      in Class 2 right side where it represented 44.44% of
                     The participants were instructed to chew each food         all class 2 subjects (25% for Class 1 right side, 0% for
                     on the right side, on the left side and bilaterally,       Class 3 right side).
                     and break the food in as many pieces as possible           For the left Molar Class 1, 2 and 3 the presence of
                     without swallowing, since the food particles had to        the Deep Bite was present in 27.27%, 33.33% and
                     be collected at the end of each chewing cycle for          33.33% of cases.
                     separate evaluation.                                       A bilateral Crossbite was detected in 17.39% of
                     A resting time of at least 30 seconds was allowed          probands (4 cases) and a monolateral crossbite
                     between recordings. The recording hardware was             was present in 2 cases only (8.7%). No proband had
                     then removed, and the proband was asked to                 scissor bite.
                     identify and score discomforts so that they could be       The quality of the Occlusal Surfaces (Tabs. 5 and
                     collected and stored within the database.                  6) was rated as poor for the right side on 9 counts
                     For each proband the maximum ‘s’ displacement              (39.1%), and on 8 counts for the left (34.8%).
                     of the Temporomandibular Joint Hinge Axis during           A Clear Buccal Intercuspation was found for 14
                     the 4 baseline movements and during the chewing            subjects (60.9%). Missing Premolars were found in
                     sequences was taken from the software analysis for         one proband only (4.3%) with no edentulous gap
                     both right and left condyle in millimeters (s, mm). For    between tooth 1.4 and tooth 1.6. Missing Molars
                     each chewing sequence, for SFM and NF, the data in         were observed in 6 cases (26.1%). Distal Restorations
                     Table 3 were collected from the appropriate tool in        were present in 7 subjects (30.43%).
                     the software and stored. For each chewing sequence,
                     SFM and NF, the data in Table 4 were retrieved with        3.2. Statistical Analyses
                     the aid of the online tool SketchAndCalc™ (iCalc Inc,      3.2.1. Condylographic Tracings for Working and Non-
                     2017 Elliott Dobbs, www.sketchandcalc.com) and             Working Sides with SFM and NF
                     used for further calculations (Fig. 4).                    For both food types, the working sides’ tracings (s,
                     All Descriptive Statistics and Tests were carried out      mm) were shorter than the non-working sides (SFM
                     with IBM SPSS Statistics for Windows, Version 24.0         ws mean 4.9 mm nws 6.8 mm; NF ws mean 3.6 mm
                     AND 25.0 Armonk, NY IBM Corp. (Released from               nws 5.3 mm; paired t test set at 95% CI p=0.000 for
                     2016).                                                     SFM and p=0.000 for NF). The difference by hardness
                                                                                on both ws and nws is not detectable. Nevertheless,
                     3. RESULTS                                                 all SFM compared to the NF s traits were significantly
                                                                                different, with SFM having larger displacements in
                     3.1. Descriptive Analysis of Subjects                      mm (SFM s mean 5.75 mm; NF 4.56; paired t test set
                     There were 14 females (60.87%) and 9 males (39.13%).       at 95% CI p=0.000).
                     The subjects’ age ranged from 18 to 64 years of age        3.2.2. Condylographic Tracings’ Distinctive Path
                     (mean age 37.74 ±12.53).                                   Inclination SCI° for Working and Non-Working Sides
                     The Molar Class for the right side was found to be         with SFM and NF
                     Class 1 in 52.17% of subjects, Class 2 in 39.13%           For the SCI° (path inclination) SFM ws and nws were
                     and Class 3 in 8.70% of probands. For the left side,       compared, with the nws showing a flatter inclination
                     the percentages were 47.83%, 26.09% and 26.09%             as expected (mean ws=61.12°, mean nws=53.31°),
                     respectively. For both sides Molar Class 1 was nearly      which was statistically different from the steeper
                     half of the total and an Asymmetric Molar Occlusion        inclination of the ws as tested with a paired t test



    58               Stoma Edu J. 2021;8(1): 52-64                                                  pISSN 2360-2406; eISSN 2502-0285
Condylographic recording of chewing function
                                                                                                                                             www.stomaeduj.com




                                                                                                                                           Original Articles
Figure 9. Male 31 yo, Asymmetric Molar Class (Right side Class 1, Left side Class 2).


set at 95% CI (p=0.000). Since the distribution of                              4. DISCUSSION
these data was not normal for SCI° SFM medium
Left chewing and SFM hard Left chewing, a non-                                  As there is increasing evidence indicating that
parametric test was also carried out (Wilcoxon                                  oral health has an impact on Public Health issues,
Signed Rank Test with significance level at 0.05,                               and not solely on Individual Health, it is important
p=0.01 and 0.003 respectively). The NF chewing SCI°                             to understand and maintain the mastication tool
were also compared for ws and nws by means of a                                 properly fitted for its neurobiological objectives as
parametric and a non-parametric test, since even                                well as nutritional ones.
here the normal distribution of data was not the case                           What is expected from an ‘ideal’ mastication is, in
at all times. Both the paired t-test and the Wilcoxon                           this respect, of the utmost importance. If teeth are
Signed Rank Test allowed to highlight a significant                             to be seen as refined, precise and sophisticated
difference in steepness of condylar path inclination.                           proprioceptors, then the scientific community’s
3.2.3. Condylographic Distinctive Chewing Pattern                               task is to test, assess and restore them accordingly.
for Working and Non-Working Sides with SFM and                                  This is the assumption behind this work, which is an
NF                                                                              offspring of previous ones which aimed at studying
The presence of a Distinctive Chewing Pattern was                               human mastication quantitatively and qualitatively
tested against the Quality of Occlusion Surfaces                                [22-26]. The Reader might want to know that other
Right and Left but no significant correlation was                               recorded condylographic parameters and chewing
observed (χ2 p=0.343 right side p=0.577 left side).                             scores had to be kept out of this publication for
A significant correlation was observed instead for                              space reasons (number of particles chewed, scores,
the variable Missing Molars and the absence of a                                number of chewing strokes, rotational angle
Distinctive Pattern (Fisher Exact Test p= 0.006). The                           GAMMA° according to the different food hardness).
variable Gender and Presence of Distal Restorations                             The population of the present study encompassed
did not yield a statistically significant result (Fisher                        diverse occlusal features, but it was a small one,
Exact Test p= 0.064).                                                           nevertheless it allowed the Investigators to set some
3.2.4. Condylographic Chewing Tracings’ Areas and                               ground for new hypotheses for future studies, and
Ratios with SFM and NF                                                          make this an explorative study on mastication and
The mere assessment of areas in mm2 showed few                                  its recording. Females showed more absence of a
statistically significant results, but an observed                              clear intercuspation as opposed to males, and they
tendency to have nws with bigger areas than ws for                              had a poorer occlusion, more occlusal restorations
Molar Class 1 and 2.                                                            and, most importantly, less presence of a distinctive
However, assessment through ratios allowed the                                  chewing pattern. Yet, the females here were the
Authors to expressly identify the predominance                                  group with the most frequent ‘ideal’ Class 1 occlusion
of transversal movement during chewing over the                                 (81%), and all Class 1s overall have 72% of clear
sagittal one across all SFM and NF chewing (right side                          buccal intercuspation. As elsewhere highlighted, this
chewing, left and bilateral). Statistically significant                         combination of findings suggests that the Molar
results were retrieved for the variables Quality                                Class alone is not a sufficient indicator at all for an
of Occlusion (poor, average, good Kruskal-Wallis                                ideal or functional mastication [48]. Monolateral
max p=0.42), Bilateral Crossbite (Mann-Whitney U                                Crossbite cases were too few to infer correlations.
max p=0.048), Missing Molars (Mann-Whitney U                                    Condylography really fulfilled the task of showing
max p=0.041), Clear Buccal Intercuspation (Mann-                                geometrical features of working and non-working
Whitney U max p=0.040), Distal Restorations (Mann-                              sides for SFM and NF: for both food types the working
Whitney U max p=0.041) and most importantly                                     sides were in fact shorter than the non-working sides.
Asymmetric Molar Class.                                                         This comes helpful in research settings in that SFM,
This latter variable in particular, gave significant                            which is not a vegetable but is still food, is generally
results for all SFM hardness and for the NF too (for                            chewed with the expected pattern that NF normally
space reasons only these results are displayed in                               shows, but it has the potential to stress and highlight
Figs. 7 and 8).                                                                 characteristics which small, easily chewed NFs may


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                     Tanteri G, et al.
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 Original Articles




                      Figure 10. Condylographic Recording during chewing of SFM and NF (only soft and hard SFM, and salad leaf chewing are displayed for space reasons)
                     by proband in Figure 9. Non-harmonic left side tracings with a very wide transversal component can be observed for SFM and NF chewing.



                     not have the power to exhibit. Much like many other                       the single areas retrieved for all foods, all sides and
                     clinical tests which can be performed at rest, but are                    all planes (sagittal, frontal and cranial), but ratios
                     sometimes required to be performed under physical                         between the sagittal plane and the transversal
                     or drug-induced stress to really recreate a condition                     planes were also calculated, so as to minimize the
                     or provoke one, the SFM chewing test might prove                          effect due to individual sizes, and enhance the more
                     the treadmill test for the masticatory system. The                        robust meaning of sagittal to transversal ratios. As
                     results with nuts and carrots have shown in fact that                     the ratio decreases, both for the sagittal:frontal and
                     every proband can chew on them with no trouble                            the sagittal:cranial dimensions, then the transversal
                     regardless of the occlusal quality, missing teeth                         quantity of movement becomes predominant over
                     and so forth. One single salad leaf is instead more                       the sagittal one. Graphical representation of areas in
                     demanding, since it can be properly torn only when                        mm2, divided by ws and nws and molar class right and
                     the occlusal quality is maintained, for it requires                       left, was difficult to interpret at a first glance and no
                     closeness of upper and lower teeth which get to                           particular difference or feature stood out. When the
                     slide on their buccal and lingual slopes. If these                        chewing data were assessed through the ratios one
                     are lost then a grinding movement between flatter                         can see that the ‘good’ quality of the occlusion right
                     surfaces occurs and this sets the basis for a more                        had bigger nws ratios (more sagittal component) for
                     horizontal/transversal movement rather than a                             SFM soft and medium (this difference was not visible
                     vertical/sagittal one. All lengths ‘s’ of the SFM sagittal                for SFM hard), as compared to the average and poor
                     tracings were numerically bigger than all lengths of                      right occlusions (more transversal component). A
                     NF sagittal tracings and this might be the effect of                      similar trend could be seen for the nws ratios for the
                     the properties of SFM (standard size for instance).                       left qualities of occlusion, but not for every single
                     For SCI° (condylar path inclination), SFM ws and nws                      ratio and hardness of SFM.
                     were compared, nws showing a flatter inclination as                       The ws ratios were smaller in poor right occlusions
                     expected, which was statistically different from the                      as compared to the ws ratios of the the average and
                     steeper inclination of the ws. The same held true for                     good occlusions, supporting the hypothesis that
                     NF. The assessment of the chewing tracings’ areas                         even in working sides there is a more transversal
                     was the most demanding and most interesting                               component in flatter occlusal qualities. The same
                     chapter in this explorative study. Not only were                          could be seen for the left qualities of occlusion.



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Similarly, when looking at the NF ratios, the poor         5. CONCLUSIONS




                                                                                                                      Original Articles
occlusions right and left had smaller ratios compared
to average occlusion, but not as much compared             As highlighted in previous works, the geriatric
to the good occlusion where differences were               population is highly affected by cognitive impair-
mostly seen in the sagittal: cranial plane ratios. This    ment and more exposed to pureed, blended and
sagittal:cranial ratio looks especially useful when        mashed food. At times it is because dysphagia is
looking at differences in NF, since the ‘s’ displacement   present, however in many facilities prescription of
is already significantly shorter in NF than SFM, and       pureed food is offered to many without real reasons
perhaps more understandable on the cranial plane           behind it. MTF (Modified Texture Food) is often
instead of the frontal one. For a similar reason ws        poorer in nutritional content and not very accepted
ratios in NF show little or inconsequent differences       and therefore eaten less despite the apparent
among the various occlusal qualities, since the range      easiness in swallowing it [49].
of the areas on working sides is already quite small       Like others, Dementia is a delicate Public Health
in mm2. Another difference between the ratios can          issue in that it directly affects patients and families,
be detected between the ws ratios of SFM and NF            it requires a very demanding set of measures to
in subjects who have distal restorations and subjects      satisfy the need and quality of life of both, and
who do not have distal restorations (NF nut is the         it tackles many aspects of preventive medicine.
only food which does not show this as clearly), with       Needless to say, it is a financial dilemma for many
the Distal Restoration Group displaying smaller            and it encompasses a very transversal series of
ratios (therefore a more transversal component). The       medical specialties, odontology being one of the
same observation could not be made for the nws.            most recent. Prevention is crucial as medical therapy
Probands without Clear Buccal Intercuspation               is at present unable to address Dementia, resulting
display smaller ratios for NF in the nws than probands     in a frustrating series of events which lead to smaller
with Clear Buccal Intercuspation. Ws show the same         chance of detecting other diseases, smaller response
difference but only in sagittal: cranial evaluation. The   to treatments in general, reduced life expectancy
above-mentioned observations have been tested              and uncontrolled disease progression [6].
(for areas and ratios, for SFM and NF) and differences     A better understanding of the significance and role
have been found to be statistically significant. All       of dental elements as singular units in neurological
differences in the sagittal and transversal areas in       modulation could empower knowledge about dental
mm2 provide food for thought in that they indicate a       risk factors and perhaps make them modifiable, and
purely numerical size discrepancy which could hide         this would raise new awareness to be transferred to
or be related to other ‘size’ parameters not taken into    researchers, physicians and most importantly the
account in this study. Anyway, it is the difference or     population. Bearing this in mind, proper mastication
even inversion of the sagittal to transversal ratios, in   should be guaranteed to avoid malnutrition in
Bilateral Crossbite, Missing Molars and Asymmetric         those populations where cognitive impairment
Molar Class subjects, that really supports the idea        has already occurred, and to at least maintain their
that these occlusal features and malocclusions are         general health status. Studies on the chewing effi-
related to a higher transversal displacement during        ciency of these very populations have shown that
chewing cycles, usually with the non-working side          Dementia patients eat slowly and therefore less, have
performing very wide movements (see Figs. 9 and 10).       uncoordinated masticatory activities with chewing
The findings in this explorative study suggest a           strokes accompanied by facial mimic movements,
number of considerations. Transveral stability in          and most importantly that it is very hard to assess
occlusion (granted by one-to-two tooth contacts            their chewing performance. At the same time, it is
sagittally, and by lingual occlusion transversally)        by now widely recognized that chewing positively
needs to be looked at and restored/provided for            affects cognitive functions with respect to memory
accordingly. The quality of occlusion is a crucial         and learning, and that masticatory hypofunction is
feature: restorative procedures which aim at restoring     independently related to cognitive impairment [50].
quadrants or single elements in flat occlusions need       Mastication studies have historically been conducted
to be looked at critically. Missing and unreplaced         by dental researchers to highlight features and risk
molars correlate with dysfunctional chewing patt-          factors related to Temporomandibular Disorders, to
erns. Molar Class has already shown little signifi-        understand human stress-management strategies,
cance and therefore it is not a good indicator for         or even to assess orthodontic treatments, full den-
describing malfunctions or chewing differences.            tures, prosthodontic restorations and functions
Some of the unexpected chewing patterns may be             like speech and bruxism. More recent evidence on
due to undetected skeletal asymmetry of the cranial        Public Health impact of mastication urges scien-
base which does not necessarily correlate with an          tists to identify occlusal characteristics which
asymmetry in molar class. SFM and condylographic           interfere with a healthy masticatory function, so
recording can be exploited as a stress test for the        as to pinpoint preventive measures or minimize
detection of incapability in chewing stiff meats or        health impairments. The findings presented here
other nutrient food.                                       are supported by the extensive previous works



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                     Tanteri G, et al.
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                     of authors who approached their research with                           instance) and even though some differences were
 Original Articles   different apparatuses. This study’s aim was to identify                 statistically significant, a higher number of cases,
                     a correlation between specific occlusal features and                    a more robust study design and a less numerous
                     what is so far known about the characteristics of                       choice of outcomes might allow to draw more
                     ‘dysfunctional chewing patterns’. The results from                      powerful conclusions and influence clinical work.
                     chewing tests by means of a Standardized Food in
                     combination with condylographic studies should                          CONFLICT OF INTEREST
                     be promoted in the future to better understand                          The authors declare no conflict of interest.
                     chewing patterns, but most importantly to make a
                     statement concerning which occlusal characteristics                     ACKNOWLEDGMENTS
                     are to be detected early, which are to be avoided in
                     rehabilitation procedures, and which goal should                        The Authors wish to thank Dr. Eugenio Tanteri for providing
                     occlusion therapy pursuit. In the near future, indivi-                  hardware for the study.
                     dual compensatory capabilities should not be called
                     upon to excuse poor occlusal therapies, and other                       AUTHOR CONTRIBUTIONS
                     conditions within the psychosocial sphere should
                     no longer justify a sudden or progressive onset of                      GT: contributed to the study design, protocol, data gathering,
                     stomatognathic symptoms. This study’s limitations                       analysis, manuscript preparation. CT: contributed to the study
                     are surely related to the small number of cases. The                    design and manuscript revision. GS: contributed to the concept,
                     study design did not require a minimum number of                        study design, analysis and interpretation of data.
                     occlusal patterns (such as monolateral crossbite for




                     REFERENCES
                     1. Mattila KJ, Nieminen MS, Valtonen VV, et al. Association             10. Gibbs CH, Wickwire NA, Jacobson AP, et al. Comparison
                     between dental health and acute myocardial infarction. BMJ.             of typical chewing patterns in normal children and adults.
                     1989;298(6676):779-781. doi: 10.1136/bmj.298.6676.779. PMID:            J Am Dent Assoc. 1982;105(1):33-42. doi: 10.14219/jada.
                     2496855; PMCID: PMC1836063.                                             archive.1982.0073. PMID: 6955363.
                     Google Scholar Scopus WoS                                               Full text links CrossRef PubMed Google Scholar Scopus WoS
                     2. DeStefano F, Anda RF, Kahn HS, et al. Dental disease and risk of     11. Felício CM, Melchior Mde O, Silva MA, Celeghini
                     coronary heart disease and mortality. BMJ. 1993;306(6879):688-          RM. [Masticatory performance in adults related to
                     691. doi: 10.1136/bmj.306.6879.688. PMID: 8471920; PMCID:               temporomandibular disorder and dental occlusion]. Pro
                     PMC1677081.                                                             Fono. 2007;19(2):151-158. Portuguese. doi: 10.1590/s0104-
                     Full text links CrossRef PubMed Google Scholar Scopus WoS               56872007000200003. PMID: 17710341.
                     3. Liljestrand JM, Havulinna AS, Paju S, et al. Missing teeth predict   PubMed Google Scholar
                     incident cardiovascular events, diabetes, and death. J Dent Res.        12. Piancino MG, Kyrkanides S. Understanding masticatory
                     2015;94(8):1055-1062. doi: 10.1177/0022034515586352. PMID:              function in unilateral crossbites. John Wiley & Sons Inc; 2016. ISBN:
                     25991651.                                                               9781118971871. doi:10.1002/9781118971901.
                     Full text links CrossRef PubMed Google Scholar Scopus WoS               CrossRef Google Scholar Scopus WoS
                     4. Offenbacher S, Beck JD. Commentary: changing paradigms               13. Lewin A. Electrognathographics. An atlas for diagnostic
                     in the oral disease-systemic disease relationship. J Periodontol.       procedures and interpretations. Berlin: Quintessence Publishing
                     2014;85(6):761-764. doi: 10.1902/jop.2014.140115. PMID:                 Co. Inc.; 1985. ISBN: 9780867151565.
                     24875011.                                                               14. Moss ML. A theoretical analysis of the functional matrix. Acta
                     Full text links CrossRef PubMed Google Scholar WoS                      Biotheor. 1968;18(1):195-202. doi: 10.1007/BF01556727. PMID:
                     5. Shen T, Lv J, Wang L, et al. Association between tooth loss          4984482.
                     and dementia among older people: a meta-analysis. Int J Geriatr         Google Scholar
                     Psychiatry. 2016;31(8):953-955. doi: 10.1002/gps.4396. PMID:            15. Kikui M, Ono T, Kokubo Y, et al. Relationship between
                     26644219.                                                               metabolic syndrome and objective masticatory performance in a
                     Full text links CrossRef PubMed Google Scholar Scopus WoS               Japanese general population: the Suita study. J Dent. 2017;56:53-
                     6. Noble JM, Scarmeas N, Papapanou PN. Poor oral health as a            57. doi: 10.1016/j.jdent.2016.10.014. PMID: 27793706.
                     chronic, potentially modifiable dementia risk factor: review of the     Full text links CrossRef PubMed Google Scholar Scopus WoS
                     literature. Curr Neurol Neurosci Rep. 2013;13(10):384. doi: 10.1007/    16. Gambareli FR, Serra MD, Pereira LJ, Gaviao MB. Influence
                     s11910-013-0384-x. PMID: 23963608; PMCID: PMC6526728.                   of measurement technique, test food, teeth and muscle force
                     Full text links CrossRef PubMed Google Scholar Scopus WoS               interactions in masticatory performance evaluation. Review
                     7. Farahani RM, Simonian M, Hunter N. Blueprint of an ancestral         Article. J Texture Stud. 2007;38(1):2-20. https://onlinelibrary.wiley.
                     neurosensory organ revealed in glial networks in human dental           com/doi/full/10.1111/j.1745-4603.2007.00083.x
                     pulp. J Comp Neurol. 2011;519(16):3306-3326. doi: 10.1002/              CrossRef Google Scholar
                     cne.22701. PMID: 21681747.                                              17. Helkimo E, Carlsson GE, Helkimo M. Chewing efficiency and
                     Full text links CrossRef PubMed Google Scholar Scopus WoS               state of dentition. A methodologic study. Acta Odontol Scand.
                     8. Chen H, Iinuma M, Onozuka M, Kubo KY. Chewing maintains              1978;36(1):33-41. doi: 10.3109/00016357809026364. PMID:
                     hippocampus-dependent cognitive function. Int J Med Sci.                273364.
                     2015;12(6):502-509. doi: 10.7150/ijms.11911. PMID: 26078711;            Full text links CrossRef PubMed Google Scholar Scopus
                     PMCID: PMC4466515.                                                      18. Kapur KK, Soman SD. Masticatory performance and efficiency
                     Full text links CrossRef PubMed Google Scholar Scopus WoS               in denture wearers. 1964. J Prosthet Dent. 2006;95(6):407-411. doi:
                     9. Gibbs CH, Mahan PE, Lundeen HC, et al. Occlusal forces during        10.1016/j.prosdent.2006.03.012. PMID: 16765149.
                     chewing--influences of biting strength and food consistency.            Full text links CrossRef PubMed Google Scholar
                     J Prosthet Dent. 1981;46(5):561-567. doi: 10.1016/0022-                 19. Kimoto K, Garrett NR. Effect of mandibular ridge height on
                     3913(81)90247-x. PMID: 6946223.                                         masticatory performance with mandibular conventional and
                     Full text links CrossRef PubMed Google Scholar Scopus WoS               implant-assisted overdentures. Int J Oral Maxillofac Implants.
                                                                                             2003;18(4):523-530. PMID: 12939003.
                                                                                             PubMed Google Scholar Scopus WoS




    62               Stoma Edu J. 2021;8(1): 52-64                                                              pISSN 2360-2406; eISSN 2502-0285
Condylographic recording of chewing function
                                                                                                                                               www.stomaeduj.com



20. Schneider G, Senger B. Clinical relevance of a simple               37. Batty GD, Li Q, Huxley R, et al. Oral disease in relation to




                                                                                                                                             Original Articles
fragmentation model to evaluate human masticatory                       future risk of dementia and cognitive decline: prospective cohort
performance. J Oral Rehabil. 2002;29(8):731-736. doi:                   study based on the action in diabetes and vascular disease:
10.1046/j.1365-2842.2002.00967.x. PMID: 12220339.                       Preterax and Diamicron modified-release controlled evaluation
Full text links CrossRef PubMed Google Scholar Scopus WoS               (ADVANCE) trial. Eur Psychiatry. 2013;28(1):49-52. doi: 10.1016/j.
21. Pocztaruk Rde L, Frasca LC, Rivaldo EG, et al. Protocol for         eurpsy.2011.07.005. PMID: 21964484; PMCID: PMC4170753.
production of a chewable material for masticatory function tests        Full text links CrossRef PubMed Google Scholar WoS
(Optocal - Brazilian version). Braz Oral Res. 2008;22(4):305-310.       38. Bergdahl M, Habib R, Bergdahl J, et al. Natural teeth and
doi: 10.1590/s1806-83242008000400004. PMID: 19148384.                   cognitive function in humans. Scand J Psychol. 2007;48(6):557-
Full text links CrossRef PubMed Google Scholar                          565. doi: 10.1111/j.1467-9450.2007.00610.x. PMID: 18028078.
22. Slavicek G, Soykher M, Gruber H, et al. A novel standard            Full text links CrossRef PubMed Google Scholar
food model to analyze the individual parameters of human                39. Hansson P, Sunnegårdh-Grönberg K, Bergdahl J, et al.
mastication. Int J Stomatol Occlusion Med. 2009;2(4):163-174. doi:      Relationship between natural teeth and memory in a healthy
10.1007/s12548-009-0029-5.                                              elderly population. Eur J Oral Sci. 2013;121(4):333-340. doi:
CrossRef Google Scholar                                                 10.1111/eos.12060. PMID: 23841785.
23. Slavicek G, Soykher M, Gruber H, et al. [Case studies on the        Full text links CrossRef PubMed Google Scholar Scopus WoS
analysis of chewing part 1: Standard Analysis]. Stomatologie.           40. Ishikawa T, Ikeda M, Matsumoto N, et al. A longitudinal
2009;106(7):119-129. German. doi: 10.1007/s00715-009-0099-4.            study regarding conversion from mild memory impairment
24. Slavicek G, Soykher M, Gruber H, et al. [Case studies on            to dementia in a Japanese community. Int J Geriatr Psychiatry.
the analysis of chewing part 2: Special analysis options].              2006;21(2):134-139. doi: 10.1002/gps.1437. PMID: 16416466.
Stomatologie. 2009;106(8):137-148. German.                              Full text links CrossRef PubMed Google Scholar Scopus WoS
doi: 10.1007/s00715-009-0103-z.                                         41. Stewart R, Stenman U, Hakeberg M, et al. Associations
25. Slavicek G, Soykher M, Gruber H, et al. [Case studies on            between oral health and risk of dementia in a 37-year follow-
the analysis of chewing part 3: Analysis of cusp movements].            up study: the prospective population study of women in
Stomatologie. 2010;107(1):1-7. German. doi: 10.1007/s00715-010-         Gothenburg. J Am Geriatr Soc. 2015;63(1):100-105. doi: 10.1111/
0107-8.                                                                 jgs.13194. PMID: 25597561.
26. Slavicek G, Soykher M, Soykher M, et al. Relevance of a             Full text links CrossRef PubMed Google Scholar Scopus WoS
standard food model in combination with electronic jaw                  42. Onozuka M, Watanabe K, Fujita M, et al. Changes in the
movement recording on human mastication pattern analysis. Adv           septohippocampal cholinergic system following removal
Biosci Biotechnol. 2010;1(02):68-78. doi: 10.4236/abb.2010.12011        of molar teeth in the aged SAMP8 mouse. Behav Brain Res.
CrossRef Google Scholar                                                 2002;133(2):197-204. doi: 10.1016/s0166-4328(02)00006-2. PMID:
27. Piehslinger E, Celar AG, Celar RM, Slavicek R. Computerized         12110453.
axiography: principles and methods. Cranio. 1991;9(4):344-355.          Full text links CrossRef PubMed Google Scholar Scopus WoS
doi: 10.1080/08869634.1991.11678382. PMID: 1820834.                     43. Watanabe K, Tonosaki K, Kawase T, et al. Evidence for
Full text links CrossRef Google Scholar WoS                             involvement of dysfunctional teeth in the senile process in the
28. Eke PI, Dye BA, Wei L, et al. Prevalence of periodontitis           hippocampus of SAMP8 mice. Exp Gerontol. 2001;36(2):283-295.
in adults in the United States: 2009 and 2010. J Dent Res.              doi: 10.1016/s0531-5565(00)00216-3. PMID: 11226743.
2012;91(10):914-920. doi: 10.1177/0022034512457373. PMID:               Full text links CrossRef PubMed Google Scholar Scopus WoS
22935673.                                                               44. Mori D, Katayama T, Miyake H, et al. Occlusal disharmony
Full text links CrossRef PubMed Google Scholar Scopus WoS               leads to learning deficits associated with decreased cellular
29. Mojon P, Thomason JM, Walls AW. The impact of falling rates         proliferation in the hippocampal dentate gyrus of SAMP8
of edentulism. Int J Prosthodont. 2004;17(4):434-440. PMID:             mice. Neurosci Lett. 2013 Feb 8;534:228-232. doi: 10.1016/j.
15382779.                                                               neulet.2012.12.004. PMID: 23262093.
Full text links CrossRef PubMed Google Scholar Scopus WoS               Full text links CrossRef PubMed Google Scholar Scopus WoS
30. WHO International. Duthey B. Alzheimer Disease and other            45. Ichihashi Y, Arakawa Y, Iinuma M, et al. Occlusal disharmony
Dementias. Background Paper 6.11. WHO; 2013.                            attenuates glucocorticoid negative feedback in aged
Available at: http://www.who.int/medicines/areas/priority_              SAMP8 mice. Neurosci Lett. 2007;427(2):71-76. doi: 10.1016/j.
medicines/BP6_11Alzheimer.pdf                                           neulet.2007.09.020. PMID: 17928141.
31. Okamoto N, Morikawa M, Tomioka K, et al. Association                Full text links CrossRef PubMed Google Scholar Scopus WoS
between tooth loss and the development of mild memory                   46. Kubo KY, Yamada Y, Iinuma M, et al. Occlusal disharmony
impairment in the elderly: the Fujiwara-kyo Study. J Alzheimers         induces spatial memory impairment and hippocampal
Dis. 2015;44(3):777-786. doi: 10.3233/JAD-141665. PMID:                 neuron degeneration via stress in SAMP8 mice. Neurosci Lett.
25362033.                                                               2007;414(2):188-191. doi: 10.1016/j.neulet.2006.12.020. PMID:
Full text links CrossRef PubMed Google Scholar Scopus WoS               17207572.
32. Gatz M, Mortimer JA, Fratiglioni L, et al. Potentially modifiable   Full text links CrossRef PubMed Google Scholar Scopus WoS
risk factors for dementia in identical twins. Alzheimers Dement.        47. Elsig F, Schimmel M, Duvernay E, et al. Tooth loss, chewing
2006;2(2):110-117. doi: 10.1016/j.jalz.2006.01.002. PMID:               efficiency and cognitive impairment in geriatric patients.
19595867.                                                               Gerodontology. 2015;32(2):149-156. doi: 10.1111/ger.12079.
Full text links CrossRef PubMed Google Scholar Scopus                   PMID: 24128078.
33. Stein PS, Desrosiers M, Donegan SJ, et al. Tooth loss,              Full text links CrossRef PubMed Google Scholar Scopus WoS
dementia and neuropathology in the Nun study. J Am Dent Assoc.          48. Slavicek G. The influence of occlusion on masticatory
2007;138(10):1314-1322; quiz 1381-1382. doi: 10.14219/jada.             efficiency considering relevant influencing factors. Stoma Edu J.
archive.2007.0046. PMID: 17908844.                                      2020;7(3):197-207 https://doi.org/10.25241/stomaeduj.2020.7(3).
Full text links PubMed Google Scholar Scopus WoS                        art.6
34. Takeuchi K, Izumi M, Furuta M, et al. Posterior teeth occlusion     Google Scholar
associated with cognitive function in nursing home older                49. Keller H, Chambers L, Niezgoda H, Duizer L. Issues associated
residents: a cross-sectional observational study. PLoS One.             with the use of modified texture foods. J Nutr Health Aging.
2015;10(10):e0141737. doi: 10.1371/journal.pone.0141737. PMID:          2012;16(3):195-200. doi: 10.1007/s12603-011-0160-z. PMID:
26512900; PMCID: PMC4626072.                                            22456772.
Full text links CrossRef PubMed Google Scholar Scopus WoS               Full text links CrossRef PubMed Google Scholar
35. Noble JM, Scarmeas N. Cognitive impairment. In: Lamster IB,         50. Teixeira FB, Pereira Fernandes Lde M, Noronha PA, et al.
Northridge ME, editors. Improving oral health for the elderly. New      Masticatory deficiency as a risk factor for cognitive dysfunction.
York: Springer Books; 2008.                                             Int J Med Sci. 2014;11(2):209-214. doi: 10.7150/ijms.6801. PMID:
36. Watanabe Y, Hirano H, Matsushita K. How masticatory                 24465167; PMCID: PMC3894406.
function and periodontal disease relate to senile dementia. Jpn         Full text links CrossRef PubMed Google Scholar Scopus WoS
Dent Sci Rev. 2014;51(1):34-40. doi: 10.1016/j.jdsr.2014.09.002
Full text links CrossRef PubMed Google Scholar Scopus WoS




Stoma Edu J. 2021;8(1): 52-64                                                             pISSN 2360-2406; eISSN 2502-0285                      63
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                                                                                                         Giulia TANTERI
                                                                                  MD, MSc, Specialist in Maxillofacial Surgery
                                                                                             Private Practice - Studio Tanteri
                                                                                                                   Turin, Italy




                    CV
                    Dr. Giulia Tanteri, MD, MSc, graduated in Medicine and Surgery at the University of Turin, Turin, Italy where she subsequently
                    completed her Oral and Maxillofacial Surgery specialization. Her activity is primarily dedicated to TMJ disorders diagnostics
                    and treatment. Her research interests have focused on the instrumental assessment of the stomatognathic system and its
                    rehabilitation, head and neck reconstructive surgery and oral surgery. She currently collaborates with the Steinbeis Transfer
                    Institute for Biomedical Interdisciplinary Dentistry (Stuttgart, Germany) and works as a private practitioner in Turin, Italy.


                    Questions
                    1. Tooth loss predicts the development of MMI among the elderly:
                    qa. Absence of tooth loss and preservation of the patients’ baseline status meant no increase in risk of MMI;
                    qb. In case of periodontitis-induced tooth loss, cognitive function is worsened;
                    qc. If teeth are lost before the age of 50;
                    qd. None of the answers is correct.

                    2. Mastication influences the activity in the cerebral cortex:
                    qa. Through blood flow increase especially in the prefrontal cortex and the hippocampus, where learning
                    and memory performance reside;
                    qb. Through increase of the number of neurons and synapses;
                    qc. Mastication and physical activity are rhythmic movements and have no beneficial effects on learning
                    and spatial memory;
                    qd. Regardless of the presence of teeth.

                    3. In geriatric evaluations:
                    qa. Tooth count is the main predictive factor which should be assessed since patients are already being fed
                    on mashed food;
                    qb. Tooth count and chewing performance should both be considered;
                    qc. Chewing performance only has relevance as a stress test for the Stomatognathic System;
                    qd. Chewing performance and tooth count are both to be considered after the onset of dementia.

                    4. Recording of a healthy chewing function should possess:
                    qa. Symmetry between working and non-working sides;
                    qb. A recognizable preferred chewing side;
                    qc. No specific pattern is relevant, as long as the subject is asymptomatic;
                    qd. Repetition, reproducibility and harmony in all projections, with a distinctive scheme for working and
                    non-working sides.




    64              Stoma Edu J. 2021;8(1): 52-64                                                    pISSN 2360-2406; eISSN 2502-0285